Figure 4.

Death ligands and their receptors Death ligands and their receptors comprise of Tumor necrosis factor (TNF)- Tumor necrosis factor receptor (TNFR1), Fas ligand (FasL)/CD95L-Fas, TNF-related weak inducer of apoptosis (TWEAK/Apo3L)- TNF receptor–related apoptosis-mediating protein (TRAMP), TNF related apoptosis inducing 13 ligand (TRIAL/Apo2L)- TNF related apoptosis inducing ligand receptor (TRAIL-R1) and Tumor necrosis factor receptor type 1-associated death domain (TRADD)- Death receptor (DR6). TNF-related apoptosis-inducing ligand (TRAIL). This ligand-receptor binding interaction activate the cytoplasmic domain, consequently recruit and activates extrinsic pathway initiator caspases such as caspase -8 and caspase 10.