Table 1. Indonesian plants and/or their components that show chemopreventive activity targeting cancers’ genome instability and mutation .

Molecular target	Plant/compounds	Reference(s)
CHK 1 (↓)	Curcumin	16
ATR (↓)	Curcumin	17
Histone acetyltransferase (↓)
Brca1 (↓)

CHK1: checkpoint kinase 1; ATR: ataxia telangiectasia and Rad3-related protein; Brca1: Breast cancer type 1 susceptibility protein.

↓: indicates down-regulation of a protein and/or pathway.