Table 10 . Indonesian plants and/or their components that show chemopreventive activity targeting deregulating cellular energetics induced by cancer cells .
Molecular target | Plant/compounds | Reference(s) |
HIF-1α (↓) | Brusatol | 120 |
GLUT1(↓) | Curcumin | 121 |
Brusatol | 120 | |
PDK1 (↓) | Brusatol | 120 |
ROS (↑) | Brucein D | 122, 123 |
Xanthorrhizol | 124 | |
Curcumin | 125 |
HIF-1α: hypoxia-inducible factor-1α; GLUT1: Glucose transporter 1; PDK1: pyruvate dehydrogenase kinase 1; ROS: reactive oxygen species.
↓: indicates down-regulation of a protein and/or pathway;
↑: indicates up-regulation of a protein and/or pathway.