Table 3. Indonesian plants and/or their components that show chemopreventive activity targeting cancers’ growth suppressors .
Molecular target | Plant/compounds | Reference(s) |
p53 (↑) | Brucea javanica (aqueous extract) | 47 |
Thymoquinone | 48 | |
PTEN (↑) | Thymoquinone | 49 |
pRb(↑) | Curcumin | 50 |
Cdki (↑) | Curcumin | 50 |
PTEN: phosphatase and tensin homolog; pRb: retinoblastoma protein; Cdki: cyclin-dependent kinase inhibitor.
↑: indicates up-regulation of a protein and/or pathway.