Table 5. Indonesian plants and/or their components that show chemopreventive activity targeting cancers’ cell death .
Molecular target | Plant/compounds | Reference(s) |
Bcl-2 (↓) | Brusatol | 34 |
Brucein D | 59 | |
Curcumin | 60 | |
Brazilin | 61 | |
Pinostrobin | 62 | |
Mcl-1 (↓) | Curcumin | 60 |
Fas (↑) | Panduratin A | 37 |
TRAIL (↑) | Panduratin A | 37 |
Bcl-2: B-cell lymphoma 2; Mcl-1: Induced myeloid leukemia cell differentiation protein; TRAIL: TNF-related apoptosis-inducing ligand.
↓: indicates down-regulation of a protein and/or pathway.
↑: indicates up-regulation of a protein and/or pathway.