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. 2019 Jun 1;9(2):219–230. doi: 10.15171/apb.2019.025

Table 9. Indonesian plants and/or their components that show chemopreventive activity targeting tumor-promoting inflammation .

Molecular target Plant/compounds Reference(s)
COX-2 (↓) Brucea javanica oil 111
Panduratin A 109
Thymoquinone 66,112
Xanthorrhizol 113
Curcumin 32
iNOS (↓) Xanthorrhizol 113
NF-κB signaling (↓) Brucea javanica oil 111
Brazilin 110
Thymoquinone 112
Curcumin 114
TNF-α (↓) N. sativa (aqueous extract) 94
Curcumin 114
IL-6 (↓) N. sativa (aqueous extract) 94
Curcumin 114
IL-1b (↓) Thymoquinone 112

COX-2: cyclooxygenase 2; iNOS: nitric oxide synthase; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; TNF-α: tumor necrosis factor α; IL-6: interleukin 6; IL-1b: interleukin 1b.

↓: indicates down-regulation of a protein and/or pathway.