Table 1. Lithium salts influence on cell death of PBMC of healthy donors and alcoholics .
| Tested substrate | Healthy donors cells | Cells of patients with alcoholism | ||||
| Early apoptosis level. % | Late apoptosis/dead cells. % | Live cell.% | Early apoptosis level. % | Late apoptosis/dead cells. % | Live cells. % | |
| Intact cells (control) | 12.75 (10.56-15.40) | 10.45 (7.90-15.45) | 76.4 (70.07-83.47) | 8.77 (6.81-16.81) | 9.72 (4.75-12.74) | 80.4 (72.58-88.53) |
| Lithium carbonate | 11.26 (9.75-13.65) | 10.72 (8.35-14.37) | 78.42 (73.43-84.44) | 7.37 (5.85-11.30) | 9.25 (5.03-10.37) | 84.7 (77.16-97.98) |
| Lithium pyruvate | 11.25 (9.85-13.84) | 9.48 (7.75-12.57) | 80.17 (75.61-85.0) | 6.87 (4.04-12.55) | 6.51 (4.05-10.14) | 87.37 (77.95-91.93) |
| TBHP | 31.17 (29.99-32.48) | 48.82 (34.19-60.87) | 20.42a (8.32-31.98) | 37.75 (25.10-40.42) | 38.30 (32.30-50.76) | 20.70c (10.33-34.30) |
| TBHP+lithium carbonate | 29.39 (23.78-14.53) | 51.33 (37.48-56.21) | 16.04 (11.35-29.05) | 34.15 (29.44-41.02) | 44.05 (36.06-47.92) | 19.41 (10.79-31.37) |
| TBHP+lithium pyruvate | 18.94 (15.90-23.95) | 14.82 (11.55-31.05) | 66.56b(40.97-72.55) | 21.36 (16.70-25.16) | 13.25 (11.71-21.12) | 63.16d (48.74-70.59) |
a P < 0.001 compared to intact cells of healthy donors.
b P = 0.001 compared to cells of healthy donors incubated with TBHP alone.
c P < 0.001 compared to intact cells of patients with alcoholism.
d P = 0.003 compared to cells of healthy donors incubated with TBHP alone.
Note: Cells were cultured under normal and induced oxidative condition (n=20), Mann-Whitney test, presented as Мedian value (Q1 – Q3).