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. 2019 Jul 26;6(4):ENEURO.0236-19.2019. doi: 10.1523/ENEURO.0236-19.2019

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Copyright © 2019 Guo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 10. — Genetic loss of TRESK does not alter the excitability of small lumbar DRG neurons. A, B, The percentage of lamotrigine-sensitive persistent K⁺ currents (A) and the total persistent outward current density (B) in small-diameter DRG neurons from adult WT and TRESK KO mice (n = 14–20 neurons in each group). ***p < 0.001; one-way ANOVA with post hoc Bonferroni test, compared with the WT group. NS, No statistically significant difference. C, D, Mean rheobase (C) and R_in (D) of small IB4⁻ and IB4⁺ DRG neurons from WT and TRESK KO mice (n = 16–19 neurons in each group; for details of the intrinsic properties of DRG neurons, see Table 3). E, F, Input/output plots of the spike frequency in response to incremental depolarizing current injections in small IB4⁻ (E) and small IB4⁺ (F) DRG neurons from WT and KO mice (same neurons as in C).