Figure 11.

Both male and female TRESK KO mice show normal responses to stimuli on the hindpaw and in visceral tissues. A, Licking/jump latency on the 55°C hot plate (n = 5–6 mice in each group). B, Withdrawal latency to radiant heat stimuli on the hindpaw (n = 5–6 mice in each group). C, Withdrawal latency to cold stimuli on the hindpaw (n = 5–12 mice in each group). D, Withdrawal threshold of a mechanical stimulus on the hindpaw (von Frey hair; n = 5–6 mice in each group). The results were verified by another experimenter in a separate cohort of WT and KO littermates. E, Duration of licking the hindpaw after intraplantar injection of 0.3 µg capsaicin (in 10 µl saline with 1% DMSO, n = 5–6) or (n = 5–6 mice in each group). Vehicle injection induced <5 s licking in individual mice. F, The number of abdominal stretches produced by intraperitoneal injection of 0.6% acetic acid (n = 6–8 mice in each group).