Table 3.

Analysis of chronic stress biomarkers for HIGH and MODERATE volume exercise groups in the Breast Cancer and Exercise Trial in Alberta (2010–2013) at baseline and 24-months.

Biomarker	Na	Baseline Mean (95% CI)	24 months Mean (95% CI)	Mean change (95% CI)	Difference in mean change (95% CI)	P-value
Cortisol (nmol/L)
HIGH	168	394.1 (372.5, 415.7)	410.6 (388.5, 432.7)	19.62 (−0.73, 39.97)	−1.64 (−30.60, 27.32)	0.91
MODERATE	164	384.0 (362.4, 405.6)	408.5 (386.6, 430.4)	21.26 (0.67, 41.86)
Cortisone (nmol/L)
HIGH	168	65.26 (62.09, 68.43)	68.32 (65.25, 71.38)	2.98 (0.07, 5.88)	1.54 (−5.67, 2.59)	0.46
MODERATE	164	65.51 (62.16, 68.85)	69.94 (66.75, 73.13)	4.52 (1.58, 7.45)
Corticosterone (nmol/L)
HIGH	168	11.45 (10.19, 12.70)	12.33 (10.67, 13.98)	1.24 (−0.15, 2.62)	−0.28 (−2.25, 1.69)	0.78
MODERATE	164	9.84 (8.79, 10.88)	11.71 (10.33, 13.10)	1.52 (0.12, 2.91)
11-deoxycortisol (nmol/L)
HIGH	168	0.95 (0.84, 1.05)	1.01 (0.89, 1.14)	0.09 (−0.01, 0.19)	0.01 (−0.13, 0.15)	0.91
MODERATE	165	0.83 (0.74, 0.92)	0.94 (0.83, 1.04)	0.08 (−0.02, 0.18)
Cortisol:cortisone
HIGH	168	6.22 (5.92, 6.52)	6.20 (5.89, 6.52)	0.02 (−0.23, 0.26)	0.0 (−0.35, 0.35)	1.00
MODERATE	164	5.99 (5.74, 6.23)	6.04 (5.73, 6.35)	0.02 (−0.23, 0.27)
Cortisol:corticosterone
HIGH	168	45.84 (41.55, 50.12)	46.50 (42.87, 50.14)	−0.52 (−3.71, 2.67)	1.56 (−2.99, 6.10)	0.50
MODERATE	164	49.52 (46.19, 52.85)	46.23 (42.92, 49.53)	−2.08 (−5.31, 1.15)
Cortisol:11-deoxycortisol
HIGH	168	523.4 (485.6, 561.2)	547.4 (505.6, 589.3)	16.97 (−14.00, 47.99)	25.66 (−18.50, 69.87)	0.25
MODERATE	164	563.9 (525.4, 602.4)	548 (510.4, 585.5)	−8.69 (−40.10, 22.71)

^aOne sample contained invalid measures for 11-deoxycortisol at 12 months due to laboratory error and was excluded from analysis.