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. 2019 May 24;294(26):10055–10075. doi: 10.1074/jbc.RA118.005312

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© 2019 Singh et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — VirS-dependent gene regulation at acidic pH. Microarray studies revealed VirS-mediated differential gene regulation at acidic pH. Up-regulation of VirS at acidic pH causes change in the expression of many genes that were found to be induced and repressed at acidic pH. These genes were categorized into various classes based on their description given by Tuberculist. A, pie chart represents the categorization of various genes that are induced by VirS at acidic pH. B, pie chart represents the categorization of various genes that are repressed by VirS at acidic pH. The percentage distribution of genes is represented in both of the pie charts. C, heat map showing the expression of VirS regulated genes in M. tuberculosis Erdman, M.tbΔvirS, and M.tbΔvirSComp in response to acidic pH relative to neutral pH (>2-fold difference, p < 0.05). The figure here depicts complete linkage and was generated by employing Heatmapper software (57).