Table 3.

Linear regression model parameters of Fig. 7 data (143 data points)

Functional groups at various sites on the lithocholic acid backbone were included as independent variables in the model. Interactions between functional groups were also included. Several interactions were automatically omitted due to collinearity. R² was 0.93 with a root mean squared error of 9.5.

	Coefficient	p value
Main effects
6α-OH	−47 ± 0.5	<0.0001
7α-OH	−7 ± 0.3	0.01
7β-OH	−36 ± 0.5	<0.0001
12α-OH	44 ± 0.5	<0.0001
12β-OH	6 ± 0.4	0.2
Glycine conjugation	−16 ± 0.3	<0.0001
Taurine conjugation	6 ± 0.3	0.01
Model intercept	20 ± 0.3	<0.0001
Interactions
7α-OH–12α-OH	−11 ± 0.5	0.04
6α-OH–taurine conjugation	−19 ± 0.5	<0.0001
12α-OH–taurine conjugation	29 ± 0.5	<0.0001