Table 2.

Association analysis of SNPs of the ACTB gene with DKD.

SNP	Group	WT/HT/MT	Genotype OR (95% CI) P valuea			Allele gene
			Additive model	Dominant model	Recessive model	Major/minor	OR (95%CI)/P b	P c
rs852423		AA/AG/GG				A/G
	Case	716/648/146	1.12 (1.002–1.253)	1.157 (1.001–1.336)	1.147 (0.891–1.478)	2080/940	1.115 (0.999–1.245)	0.960
	Control	765/619/126	P = 0.046	P = 0.048	P = 0.287	2149/871	P = 0.053
rs852426		TT/TC/CC				T/C
	Case	890/518/102	1.217 (1.079–1.373)	1.226 (1.057–1.422)	1.522 (1.108–2.089)	2298/722	1.219 (1.079–1.376)	0.300
	Control	961/479/70	P = 0.001	P = 0.007	P = 0.009	2401/619	P = 0.001
rs2966449		TT/TC/CC				T/C
	Case	810/589/111	1.151 (1.025–1.293)	1.201 (1.039–1.389)	1.151 (0.865–1.533)	2289/811	1.107 (0.987–1.243)	0.307
	Control	874/540/96	P = 0.018	P = 0.013	P = 0.334	2288/732	P = 0.083

WT, wild type; HT, heterozygote; MT, mutant type.

^aAdjusted for age, gender, smoking, drinking, BMI and diabetic duration, TG, TC, HDL-C and LDL-C.

^bP value of χ² text for comparison of allele frequencies between case and control groups.

^cP value of Fisher’s exact two-sided chi-squared test for Hardy–Weinberg equilibrium.