Table 3.
Significant differentially expressed proteins identified by iTRAQ coupled with 2DLC‑MS/MS
| Accession Number | Protein Name | Gene Name | Average Ratio | ||
|---|---|---|---|---|---|
| B-ALL:Con | T-ALL:Con | T-ALL:B-ALL | |||
| ACTN1_HUMAN | Alpha-actinin-1 | ACTN1 | 7.57 | - | - |
| LDHA_HUMAN | L-lactate dehydrogenase A chain | LDHA | 2.83 | 2.28 | - |
| FINC_HUMAN | Fibronectin | FN1 | 2.33 | 2.83 | - |
| A2GL_HUMAN | Leucine-rich alpha-2-glycoprotein | LRG1 | 2.20 | 1.8 | - |
| LDHB_HUMAN | L-lactate dehydrogenase B chain | LDHB | 2.11 | - | - |
| CO3_HUMAN | Complement C3 | C3 | 2.00 | 2.21 | - |
| PVRL1_HUMAN | Poliovirus receptor-related protein 1 | PVRL1 | 2.00 | - | - |
| CD44_HUMAN | CD44 antigen | CD44 | 1.95 | 1.32 | 0.67 |
| VCAM1_HUMAN | Vascular cell adhesion protein 1 | VCAM1 | 1.95 | - | - |
| AACT_HUMAN | Alpha-1-antichymotrypsin | SERPINA3 | 1.90 | 1.55 | - |
| 1B07_HUMAN (+1) | HLA class I histocompatibility antigen, B-7 alpha chain | HLA-B | 1.75 | - | - |
| ITIH3_HUMAN | Inter-alpha-trypsin inhibitor heavy chain H3 | ITIH3 | 1.72 | 1.22 | 0.71 |
| CERU_HUMAN | Ceruloplasmin | CP | 1.67 | 1.22 | - |
| S10A8_HUMAN | Protein S100-A8 | S100A8 | 1.63 | 2.58 | - |
| APOC2_HUMAN | Apolipoprotein C-II | APOC2 | 1.60 | 0.45 | 0.28 |
| APOA2_HUMAN | Apolipoprotein A-II | APOA2 | 1.53 | 3.82 | 2.5 |
| APOC3_HUMAN | Apolipoprotein C-III | APOC3 | 1.52 | - | 0.44 |
| CSF1R_HUMAN | Macrophage colony-stimulating factor 1 receptor | CSF1R | 1.38 | 1.42 | - |
| CFAB_HUMAN | Complement factor B | CFB | 1.33 | - | 0.75 |
| ANGT_HUMAN | Angiotensinogen | AGT | 1.28 | - | - |
| PLMN_HUMAN | Plasminogen | PLG | 0.78 | - | - |
| COL11_HUMAN | Collectin-11 | COLEC11 | 0.78 | - | - |
| HEP2_HUMAN | Heparin cofactor 2 | SERPIND1 | 0.75 | - | - |
| THBG_HUMAN | Thyroxine-binding globulin | SERPINA7 | 0.75 | 0.65 | - |
| PRDX2_HUMAN | Peroxiredoxin-2 | PRDX2 | 0.75 | - | - |
| HBB_HUMAN | Hemoglobin subunit beta | HBB | 0.75 | 2.1 | 2.8 |
| TRFL_HUMAN | Lactotransferrin | LTF | 0.75 | - | - |
| RARR2_HUMAN | Retinoic acid receptor responder protein 2 | RARRES2 | 0.75 | - | - |
| ANAG_HUMAN | Alpha-N-acetylglucosaminidase | NAGLU | 0.75 | - | - |
| CLUS_HUMAN | Clusterin | CLU | 0.74 | - | - |
| FIBA_HUMAN | Fibrinogen alpha chain | FGA | 0.74 | - | - |
| SODE_HUMAN | Extracellular superoxide dismutase [Cu-Zn] | SOD3 | 0.73 | - | - |
| VTDB_HUMAN | Vitamin D-binding protein | GC | 0.72 | 0.67 | - |
| ITIH2_HUMAN | Inter-alpha-trypsin inhibitor heavy chain H2 | ITIH2 | 0.72 | 0.78 | - |
| KAIN_HUMAN | Kallistatin | SERPINA4 | 0.72 | - | - |
| ATRN_HUMAN | Attractin | ATRN | 0.68 | - | - |
| THRB_HUMAN | Prothrombin | F2 | 0.67 | 0.78 | - |
| HRG_HUMAN | Histidine-rich glycoprotein | HRG | 0.67 | 0.72 | - |
| TETN_HUMAN | Tetranectin | CLEC3B | 0.67 | 0.67 | - |
| CHLE_HUMAN | Cholinesterase | BCHE | 0.67 | - | - |
| AFAM_HUMAN | Afamin | AFM | 0.65 | 0.75 | - |
| HGFA_HUMAN | Hepatocyte growth factor activator | HGFAC | 0.65 | - | - |
| HABP2_HUMAN | Hyaluronan-binding protein 2 | HABP2 | 0.65 | 0.65 | - |
| LYSC_HUMAN | Lysozyme C | LYZ | 0.65 | - | - |
| PPBT_HUMAN | Alkaline phosphatase, tissue-nonspecific isozyme | ALPL | 0.65 | - | 1.62 |
| ADIPO_HUMAN | Adiponectin | ADIPOQ | 0.65 | - | - |
| TENX_HUMAN | Tenascin-X | TNXB | 0.61 | 0.78 | - |
| FLNA_HUMAN | Filamin-A | FLNA | 0.60 | - | 1.33 |
| PHLD_HUMAN | Phosphatidylinositol-glycan-specific phospholipase D | GPLD1 | 0.60 | - | - |
| LYVE1_HUMAN | Lymphatic vessel endothelial hyaluronic acid receptor 1 | LYVE1 | 0.60 | 0.6 | - |
| FUCO_HUMAN | Tissue alpha-L-fucosidase | FUCA1 | 0.60 | - | - |
| FIBG_HUMAN | Fibrinogen gamma chain | FGG | 0.56 | 0.56 | - |
| PGRP2_HUMAN | N-acetylmuramoyl-L-alanine amidase | PGLYRP2 | 0.55 | 0.75 | - |
| DHX9_HUMAN | ATP-dependent RNA helicase A | DHX9 | 0.55 | 0.65 | - |
| KIT_HUMAN | Mast/stem cell growth factor receptor Kit | KIT | 0.55 | - | - |
| UB2V2_HUMAN | Ubiquitin-conjugating enzyme E2 variant 2 | UBE2V2 | 0.55 | 1.45 | 2.64 |
| CADH1_HUMAN | Cadherin-1 | CDH1 | 0.55 | - | - |
| CALM_HUMAN | Calmodulin | CALM1 | 0.55 | 1.32 | 2.42 |
| FIBB_HUMAN | Fibrinogen beta chain | FGB | 0.53 | - | - |
| TAGL2_HUMAN | Transgelin-2 | TAGLN2 | 0.50 | - | 1.89 |
| FA12_HUMAN | Coagulation factor XII | F12 | 0.50 | - | 1.7 |
| SEPP1_HUMAN | Selenoprotein P | SEPP1 | 0.50 | - | 1.6 |
| TTHY_HUMAN | Transthyretin | TTR | 0.50 | 0.65 | - |
| SHBG_HUMAN | Sex hormone-binding globulin | SHBG | 0.45 | 0.55 | - |
| POSTN_HUMAN | Periostin | POSTN | 0.45 | 0.5 | - |
| TRML1_HUMAN | Trem-like transcript 1 protein | TREML1 | 0.45 | 0.6 | - |
| LUM_HUMAN | Lumican | LUM | 0.44 | 0.44 | - |
| APOA4_HUMAN | Apolipoprotein A-IV | APOA4 | 0.41 | 0.45 | - |
| COMP_HUMAN | Cartilage oligomeric matrix protein | COMP | 0.41 | 0.5 | - |
| MTPN_HUMAN | Myotrophin | MTPN | 0.40 | - | - |
| TPM4_HUMAN | Tropomyosin alpha-4 chain | TPM4 | 0.36 | 0.77 | 2.13 |
| TYB4_HUMAN | Thymosin beta-4 | TMSB4X | 0.35 | 0.65 | - |
| GP1BA_HUMAN | Platelet glycoprotein Ib alpha chain | GP1BA | 0.35 | 0.55 | - |
| SPRC_HUMAN | SPARC | SPARC | 0.35 | 0.5 | - |
| GPV_HUMAN | Platelet glycoprotein V | GP5 | 0.35 | 0.75 | 2.14 |
| LEG1_HUMAN | Galectin-1 | LGALS1 | 0.35 | - | 2.71 |
| TSP1_HUMAN | Thrombospondin-1 | THBS1 | 0.30 | 0.55 | 1.83 |
| PI16_HUMAN | Peptidase inhibitor 16 | PI16 | 0.23 | 0.23 | - |
| CXCL7_HUMAN | Platelet basic protein | PPBP | 0.18 | 0.41 | 2.25 |
| CO1A1_HUMAN | Collagen alpha-1(I) chain | COL1A1 | 0.18 | 0.18 | - |
| PLF4_HUMAN | Platelet factor 4 | PF4 | 0.15 | 0.25 | - |
| APOH_HUMAN | Beta-2-glycoprotein 1 | APOH | - | 0.74 | - |
| ZA2G_HUMAN | Zinc-alpha-2-glycoprotein | AZGP1 | - | 1.23 | - |
| APOE_HUMAN | Apolipoprotein E | APOE | - | 0.71 | - |
| PLSL_HUMAN | Plastin-2 | LCP1 | - | 2.19 | - |
| IC1_HUMAN | Plasma protease C1 inhibitor | SERPING1 | - | 0.72 | - |
| VWF_HUMAN | von Willebrand factor | VWF | - | 2.36 | - |
| PERM_HUMAN | Myeloperoxidase | MPO | - | 1.65 | - |
| PPIA_HUMAN | Peptidyl-prolyl cis-trans isomerase A | PPIA | - | 2.05 | 2.28 |
| CADH5_HUMAN | Cadherin-5 | CDH5 | - | 0.75 | - |
| PON1_HUMAN | Serum paraoxonase/arylesterase 1 | PON1 | - | 3.35 | 3 |
| PROF1_HUMAN | Profilin-1 | PFN1 | - | 1.53 | 1.86 |
| LYAM1_HUMAN | L-selectin | SELL | - | 3.05 | 3.81 |
| SAA1_HUMAN | Serum amyloid A-1 protein | SAA1 | - | 1.59 | - |
| SAMP_HUMAN | Serum amyloid P-component | APCS | - | 1.5 | - |
| APOC1_HUMAN | Apolipoprotein C-I | APOC1 | - | 0.55 | 0.69 |
| FBLN1_HUMAN | Fibulin-1 | FBLN1 | - | 0.73 | - |
| PLTP_HUMAN | Phospholipid transfer protein | PLTP | - | 1.47 | 2 |
| 1433Z_HUMAN | 14–3-3 protein zeta/delta | YWHAZ | - | 6.75 | - |
| VIME_HUMAN | Vimentin | VIM | - | 4 | - |
| UBR1_HUMAN | E3 ubiquitin-protein ligase UBR1 | UBR1 | - | 1.3 | 1.44 |
| CAH1_HUMAN | Carbonic anhydrase 1 | CA1 | - | 1.61 | 1.61 |
| MBL2_HUMAN | Mannose-binding protein C | MBL2 | - | 0.65 | - |
| SODC_HUMAN | Superoxide dismutase [Cu-Zn] | SOD1 | - | 1.25 | - |
| SRCRM_HUMAN | Scavenger receptor cysteine-rich domain-containing protein SCART1 | - | 0.75 | - | |
| ACTS_HUMAN | Actin， alpha skeletal muscle | ACTA1 | - | 2.32 | - |
| TALDO_HUMAN | Transaldolase | TALDO1 | - | 2.17 | - |
| SAA4_HUMAN | Serum amyloid A-4 protein | SAA4 | - | 1.55 | - |
| ALDOB_HUMAN | Fructose-bisphosphate aldolase B | ALDOB | - | 0.75 | - |
| HEG1_HUMAN | Protein HEG homolog 1 | HEG1 | - | 1.89 | - |
| HBA_HUMAN | Hemoglobin subunit alpha | HBA1 | - | 1.4 | - |
| COTL1_HUMAN | Coactosin-like protein | COTL1 | - | 1.34 | 2.29 |
| STMN1_HUMAN | Stathmin | STMN1 | - | 82.71 | - |
| ICAM2_HUMAN | Intercellular adhesion molecule 2 | ICAM2 | - | 1.59 | - |
| HNRPK_HUMAN | Heterogeneous nuclear ribonucleoprotein K | HNRNPK | - | 4.94 | 4.45 |
| GDIR2_HUMAN | Rho GDP-dissociation inhibitor 2 | ARHGDIB | - | 2.35 | 3.36 |
| PEBP1_HUMAN | Phosphatidylethanolamine-binding protein 1 | PEBP1 | - | 1.7 | 1.7 |
| TARSH_HUMAN | Target of Nesh-SH3 | ABI3BP | - | 0.78 | - |
| MTG2_HUMAN | Mitochondrial ribosome-associated GTPase 2 | MTG2 | - | 0.75 | - |
| PSA1_HUMAN | Proteasome subunit alpha type-1 | PSMA1 | - | 1.95 | - |
| SH3L1_HUMAN | SH3 domain-binding glutamic acid-rich-like protein | SH3BGRL | - | 3.6 | - |
| CO4B_HUMAN | Complement C4-B | C4B | - | - | 1.29 |
| ALBU_HUMAN | Serum albumin | ALB | - | - | 1.47 |
| CBG_HUMAN | Corticosteroid-binding globulin | SERPINA6 | - | - | 1.29 |
| GPX3_HUMAN | Glutathione peroxidase 3 | GPX3 | - | - | 1.29 |
| TLN1_HUMAN | Talin-1 | TLN1 | - | - | 1.25 |
| APOF_HUMAN | Apolipoprotein F | APOF | - | - | 0.72 |
| C1QC_HUMAN | Complement C1q subcomponent subunit C | C1QC | - | - | 1.63 |