Table 2. Angina Diary–Based Outcome Measurements During the Study.
| Outcome Measure | DAM (n = 99) | NAM (n = 99) | SA (n = 101) | WL (n = 99) | P Value | Value of Pairwise Comparison | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DAM vs NAM | DAM vs SA | DAM vs WL | |||||||||
| Effect Size (95% CI) | P Valuea | Effect Size (95% CI) | P Valuea | Effect Size (95% CI) | P Valuea | ||||||
| Difference from baseline in frequency of angina attacks, mean (SD), No. | |||||||||||
| Baseline | 13.52 (5.93) | 12.94 (7.28) | 12.62 (5.64) | 14.14 (10.39) | .51 | NA | NA | NA | NA | NA | NA |
| Treatment for 1-4 wk | 5.57 (3.70) | 3.14 (4.07) | 2.00 (4.19) | 0.48 (4.50) | <.001 | NA | <.001 | NA | <.001 | NA | <.001 |
| After treatment, wk | |||||||||||
| 5-8 | 6.86 (4.24) | 3.72 (4.71) | 2.55 (4.34) | 1.94 (7.35) | <.001 | NA | <.001 | NA | <.001 | NA | <.001 |
| 9-12 | 7.32 (4.49) | 3.65 (4.59) | 2.67 (4.99) | 2.38 (7.05) | <.001 | NA | <.001 | NA | <.001 | NA | <.001 |
| 13-16 | 7.96 (5.04) | 3.89 (4.77) | 2.78 (6.08) | 2.33 (7.27) | <.001 | NA | <.001 | NA | <.001 | NA | <.001 |
| Pain severity of angina, mean (SD), VAS scoreb | |||||||||||
| Baseline | 3.75 (1.31) | 3.66 (1.37) | 3.70 (1.11) | 3.58 (1.18) | .80 | NA | NA | NA | NA | NA | NA |
| Treatment for 1-4 wk | 3.07 (1.33) | 3.26 (1.25) | 3.43 (1.07) | 3.51 (1.23) | .07 | −0.15 (−0.43 to 0.13) | .30 | −0.30 (−0.58 to −0.02) | .04 | −0.34 (−0.62 to −0.06) | .02 |
| After treatment, wk | |||||||||||
| 5-8 | 2.84 (1.40) | 3.02 (1.16) | 3.27 (1.17) | 3.44 (1.33) | .007 | −0.14 (−0.42 to 0.14) | .22 | −0.33 (−0.61 to −0.05) | .009 | −0.44 (−0.72 to −0.16) | .001 |
| 9-12 | 2.52 (1.49) | 3.12 (1.30) | 3.28 (1.27) | 3.42 (1.30) | <.001 | −0.43 (−0.71 to −0.15) | .001 | −0.55 (−0.83 to −0.26) | <.001 | −0.64 (−0.93 to −0.36) | <.001 |
| 13-16 | 2.37 (1.60) | 3.11 (1.40) | 3.17 (1.23) | 3.37 (1.29) | <.001 | −0.49 (−0.77 to −0.21) | <.001 | −0.56 (−0.84 to −0.28) | <.001 | −0.69 (−0.97 to −0.40) | <.001 |
| Use of rescue medicine, No. (%) | |||||||||||
| Baseline | 26 (26.0) | 33 (32.7) | 24 (23.5) | 31 (30.7) | .45 | NA | NA | NA | NA | NA | NA |
| Treatment for 1-4 wk | 22 (22.0) | 24 (23.8) | 25 (24.5) | 27 (26.7) | .78 | NA | NA | NA | NA | NA | NA |
| After treatment, wk | |||||||||||
| 5-8 | 14 (14.0) | 20 (19.8) | 21 (20.6) | 25 (24.8) | .50 | NA | NA | NA | NA | NA | NA |
| 9-12 | 11 (11.0) | 24 (23.8) | 19 (18.6) | 26 (25.7) | .09 | NA | NA | NA | NA | NA | NA |
| 13-16 | 11 (11.0) | 22 (21.8) | 17 (16.7) | 23 (22.8) | .24 | NA | NA | NA | NA | NA | NA |
| Score of SAS, mean (SD) | |||||||||||
| Baseline | 39.97 (7.69) | 41.12 (8.22) | 40.92 (6.96) | 41.14 (7.32) | .67 | NA | NA | NA | NA | NA | NA |
| Treatment for 1-4 wk | 37.66 (7.71) | 39.00 (6.63) | 39.38 (6.55) | 39.97 (7.33) | .15 | −0.19 (−0.46 to 0.09) | .20 | −0.24 (−0.52 to 0.04) | .11 | −0.31 (−0.59 to −0.03) | .03 |
| After treatment, wk | |||||||||||
| 5-8 | 36.79 (7.55) | 37.94 (6.46) | 38.83 (6.42) | 39.10 (7.07) | .10 | −0.16 (−0.44 to 0.12) | .26 | 0.29 (−0.57 to −0.01) | .04 | −0.32 (−0.59 to −0.03) | .02 |
| 13-16 | 35.70 (7.62) | 37.40 (6.64) | 38.22 (6.35) | 38.56 (6.55) | .02 | −0.24 (−0.52 to 0.04) | .09 | −0.36 (−0.64 to −0.08) | .01 | −0.40 (−0.68 to −0.12) | .005 |
| Score of SDS, mean (SD) | |||||||||||
| Baseline | 39.83 (8.53) | 41.37 (10.49) | 41.73 (9.05) | 41.26 (8.46) | .48 | NA | NA | NA | NA | NA | NA |
| Treatment for 1-4 wk | 38.09 (8.57) | 39.24 (9.65) | 41.13 (9.31) | 40.89 (8.91) | .07 | −0.13 (−0.40 to 0.15) | .39 | −0.34 (−0.62 to −0.06) | .02 | −0.32 (−0.60 to −0.04) | .04 |
| After treatment, wk | |||||||||||
| 5-8 | 36.95 (7.71) | 38.49 (9.30) | 40.34 (8.41) | 39.46 (8.28) | .04 | −0.18 (−0.46 to 0.10) | .21 | −0.42 (−0.70 to −0.14) | .006 | −0.31 (−0.59 to −0.03) | .04 |
| 13-16 | 35.96 (7.41) | 38.46 (9.55) | 39.90 (8.15) | 39.16 (7.60) | .008 | −0.29 (−0.57 to −0.01) | .04 | −0.51 (−0.79 to −0.22) | .001 | −0.43 (−0.71 to −0.14) | .009 |
| 6-Minute walk distance test, mean (SD), m | |||||||||||
| Baseline | 379.50 (68.47) | 394.90 (82.18) | 378.80 (78.89) | 381.0 (83.61) | .42 | NA | NA | NA | NA | NA | NA |
| Treatment for 1-4 wk | 408.60 (65.02) | 415.10 (82.63) | 384.20 (75.91) | 385.0 (77.80) | .006 | −0.09 (−0.37 to 0.19) | .56 | 0.34 (0.06 to 0.62) | .03 | 0.33 (0.05 to 0.61) | .03 |
Abbreviations: DAM, disease-affected meridian; NA, not applicable; NAM, nonaffected meridian; SA, sham acupuncture; SAS, self-rating anxiety scale; SDS, self-rating depression scale; VAS, visual analog scale; WL, wait list.
a
P value based on the Nemenyi method or Bonferroni adjustment in pairwise comparison based on data distribution. P values based on Kruskal-Wallis analysis between the 4 groups in difference from baseline in frequency of angina attacks. P values based on analysis of variance between the 4 groups in VAS, use of rescue medicine, SAS, SDS, and the 6-minute walk distance test.
b
Score range is from 0 to 10, with higher scores indicating greater pain.