Scheme 34.
Synthesis of lacosamide, (R)-2-acetamido-N-benzyl-3-methoxypropanamide (R)-130. Reagents and conditions: a) MeOH, BF3·OEt2, MeCN, 90 °C, 3 h; b) H2, 20% Pd(OH)2/C, Ac2O, EtOH, rt, 14 h; c) BnNH2, Me3Al, CH2Cl2, rt, 3 h.
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