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Synthesis of (3R,4S)-N3-Boc-3,4-diaminopentanoic acid (3R,4S)-155. Reagents and conditions: a) Ph3P=CHCOOMe, MeOH, 0 °C, 1 h; b) (S)-PhMeCHNH2, MeOH, 50 °C, 7 h; c) H2, Pd(OH)2, MeOH, rt, 4 h then Boc2O, MeOH, rt, 4 h; d) LiOH, MeOH/H2O, reflux, 6 h then Dowex 50W X2-200.
