Scheme 7.
Synthesis of (R)-mexiletine ((R)-24). Reagents and conditions: a) TsCl, TEA, DMAP, CH2Cl2, rt, 1 h; b) 2,6-dimethylphenol, K2CO3, DMF/acetone, reflux, 4 h; c) H2, Pd/C, MeOH, rt, 12 h.
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