Table 2.
Placebo (N=12) | 40 mg (N=6) | 80 mg (N=6) | 160 mg (N=8) | 320 mg (N=8) | 640 mga (N=8) | 1280 mg (N=8) | |
---|---|---|---|---|---|---|---|
Abdominal discomfort | 1 | ||||||
Abdominal pain | 1 | ||||||
Diarrhoea | 1 | ||||||
Dysgeusia | 1 | ||||||
Epigastric discomfort | 1 | ||||||
Lip ulceration | 1 | ||||||
Mouth ulceration | 1 | ||||||
Nausea | 1 | 1 | 4 | ||||
Headache | 1 | 1 | |||||
Somnolence | 1 |
Note: aIn the 640 mg of IDP-73152 mesylate, drug-related adverse event occurred in fasted state.