Figure 6.

(A) Schematic illustration of the fabrication of the glutathione (GSH)-responsive MnMoO_X nanorod for tumor theranostic application. (B) Ultraviolet–visible absorption spectra and (C) PA signal intensities of MnMoO_X-PEG after incubation with different concentrations of GSH. (D) T₁ relaxation rates of different concentrations of MnMoO_X-PEG before and after incubation with 10 mM GSH. (E) In vivo photoacoustic imaging of tumors, and (F) T₁-weighted magnetic resonance imaging (MRI) of tumor-bearing mice and corresponding T₁ signal intensity of the tumor sites before and after intravenous injection of MnMoO_X-PEG. (G) Tumor growth curves of mice for different treatment groups. Figures A to G reprinted with permission from Gong F, Cheng L, Yang N, et al. Bimetallic oxide MnMoOX nanorods for in vivo photoacoustic imaging of GSH and tumorspecific photothermal therapy. Nano Lett. 2018;18(9):6037–6044.⁷⁵ Copyright © 2018, American Chemical Society.

Abbreviations: i.v., intravenous; PEG, polyethylene glycol; PTT, photothermal therapy; GSH, glutathione; PA, photoacoustic.