Table 2.
Univariate and multivariate Cox regression analyses of risk factors associated with overall survival
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| miR-497-5p expression (low vs. high) | 4.603 | 1.914–9.465 | 0.001 | 4.116 | 1.542–8.767 | 0.005 |
| Gender (male vs. female) | 0.656 | 0.325–1.326 | 0.241 | |||
| Age (< 50 vs. ≥ 55) | 0.609 | 0.370–1.005 | 0.052 | |||
| HBsAg (negative vs. positive) | 0.918 | 0.481–1.753 | 0.796 | |||
| Cirrhosis (yes vs. no) | 1.435 | 0.886–2.325 | 0.142 | |||
| AFP (< 200 ng/mL vs. ≥ 200 ng/mL) | 1.766 | 1.092–2.857 | 0.020 | 1.548 | 0.924–2.592 | 0.097 |
| Tumor size (< 5 cm vs. ≥ 5 cm) | 1.651 | 1.007–2.707 | 0.047 | 0.718 | 0.387–1.331 | 0.293 |
| Tumor number (single vs. multiple) | 2.184 | 1.296–3.680 | 0.003 | 1.105 | 0.585–2.088 | 0.758 |
| PVTT (no vs. yes) | 3.487 | 1.852–6.564 | 0.001 | 1.229 | 0.537–2.816 | 0.626 |
| TNM stage (I/II vs. III/IV) | 3.331 | 1.989–5.578 | 0.001 | 2.401 | 0.791–2.285 | 0.171 |
| Edmondson grade (I/II vs. > II) | 4.384 | 2.561–7.505 | 0.001 | 2.768 | 1.206–6.352 | 0.016 |
AFP alpha-fetoprotein determination, PVTT portal vein tumor thrombus, HBsAg hepatitis B virus, TNM tumor node metastasis, HR hazard ratio, CI confidence interval