Table 3.
Univariate and multivariate Cox regression analyses of risk factors associated with disease-free survival
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| miR-497-5p expression (high vs. low) | 3.358 | 1.516–7.408 | 0.001 | 3.197 | 1.264–6.121 | 0.004 |
| Gender (male vs. female) | 0.379 | 0.116–1.237 | 0.108 | |||
| Age (< 50 vs. ≥ 55) | 0.501 | 0.246–1.024 | 0.058 | |||
| HBsAg (negative vs. positive) | 1.104 | 0.429–2.838 | 0.838 | |||
| Cirrhosis (no vs. yes) | 2.181 | 1.092–4.355 | 0.027 | 1.065 | 0.455–2.497 | 0.884 |
| AFP (< 200 ng/mL vs. ≥ 200 ng/mL) | 2.311 | 1.182–4.518 | 0.014 | 0.951 | 0.371–2.135 | 0.616 |
| Tumor size (< 5 cm vs. ≥ 5 cm) | 3.523 | 1.595–7.782 | 0.002 | 1.584 | 0.591–4.245 | 0.360 |
| Tumor number (single vs. multiple) | 1.652 | 0.818–3.337 | 0.162 | |||
| PVTT (no vs. yes) | 3.971 | 1.798–8.768 | 0.001 | 1.651 | 0.759–3.590 | 0.206 |
| TNM stage (I/II vs. III/IV) | 2.945 | 1.511–5.739 | 0.002 | 1.570 | 0.609–4.046 | 0.351 |
| Edmondson grade (I/II vs. > II) | 3.384 | 1.419–9.660 | < 0.01 | 5.442 | 2.778–9.714 | 0.001 |
AFP alpha-fetoprotein determination, PVTT portal vein tumor thrombus, HBsAg hepatitis B surface antigen, TNM tumor node metastasis, HR hazard ratio, CI confidence interval