Table 3.
Selected small molecule activators of NRF2 acting as NRF2-KEAP1 protein-protein interaction inhibitors.
| Compound | Type | Ref. | Patent |
|---|---|---|---|
(SRS)-5
|
1,2,3,4-Tetrahydroisoquinoline core | [112] | WO2013/067036 |
Cpd 15
|
Benzenesulfonyl-pyrimidone | [107] | WO2016/202253 |
Cpd 16
|
1,4-Diaminonaphthalene core | [107] | WO2016/202253 |
Compound 2
|
1,4-Diaminonaphthalene core | [163] | CN105566241A |
3-(Pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one (PSTC)
|
Sulfonyl coumarins | [164] | WO2015/092713 |
AN-465/144580
|
Other structure classes | [165] | JP2011/0167537 |
Compound 7
|
Arylcyclohexyl pyrazoles | [166] | WO2017060855 |