. 2019 Jul 15;2019:3984906. doi: 10.1155/2019/3984906

Table 1.

The mitochondrial function-related genes (i.e., associated with relevant GO terms according to DAVID) that change the expression in untreated (control) OXYS rats; the effect of prolonged treatment with SkQ1. Differential expression means a comparison with the control Wistar strain.

	Process	Number of DEGs in control OXYS rats	Percentage of DEGs removed by SkQ1	Gene symbols
BP	Mitochondrion organization	11	91	Sept4, Mfn1 ^∗, Spg7 ^∗, Samm50 ^∗, Jun ^∗, Mtx1 ^∗, Tomm40 ^∗, Bnip3 ^∗, Bcl2l1 ^∗, Synj2bp ^∗, Dap3 ^∗
	Generation of precursor metabolites and energy	11	91	Atp6v0c ^∗, Atp5d ^∗, Uqcrc1 ^∗, Pfkl ^∗, Hk2 ^∗, Atp5c1 ^∗, Hk1 ^∗, Cyb5b ^∗, Cat ^∗, Atp5h, Etfb ^∗
	Oxidation reduction	15	80	Cyb5r3 ^∗, Me3 ^∗, Uqcrc1 ^∗, Cyb5b ^∗, Por ^∗, Gsr, Ivd ^∗, Ndufv1 ^∗, Akr7a2 ^∗, Cat ^∗, Alkbh3 ^∗, Acad11 ^∗, Mecr, Etfb ^∗, Prodh
	Oxidative phosphorylation	5	80	Atp6v0c ^∗, Atp5d ^∗, Uqcrc1 ^∗, Atp5c1 ^∗, Atp5h
	Mitochondrial transport	4	100	Mtx1 ^∗, Tomm40 ^∗, Bnip3 ^∗, Bcl2l1 ^∗
	Apoptotic mitochondrial changes	3	100	Jun ^∗, Bcl2l1 ^∗, Dap3 ^∗

MF	Coenzyme binding	10	90	Cyb5r3 ^∗, Gsr, Acbd3 ^∗, Me3 ^∗, Ivd ^∗, Ndufv1 ^∗, Cat ^∗, Parp1 ^∗, Acad11 ^∗, Por ^∗
	Nucleotide binding	28	71	Hsp90ab1 ^∗, Cyb5r3 ^∗, Sept4, Me3 ^∗, Fastkd1, Spg7 ^∗, Abca9, Hk2 ^∗, Hk1 ^∗, Acsf2, Gsr, Ivd ^∗, Slc22a4 ^∗, Abcb10, Cat ^∗, Actb, Pdk2 ^∗, Alpk1 ^∗, Pfkl ^∗, Por ^∗, Atad1 ^∗, Acsm3, Trap1 ^∗, Hyou1 ^∗, Mfn1 ^∗, Ndufv1 ^∗, Acad11 ^∗, Parp1 ^∗
	Electron carrier activity	7	86	Cyb5r3 ^∗, Gsr, Ivd ^∗, Cyb5b ^∗, Acad11 ^∗, Etfb ^∗, Por ^∗

CC	Mitochondrion	66	76	Hsp90ab1 ^∗, Cyb5r3 ^∗, Atp5d ^∗, Spg7 ^∗, Uqcrc1 ^∗, Aurkaip1 ^∗, Nit1, Nit2, Bnip3 ^∗, Clybl, Acsf2, Gsr, Acbd3 ^∗, Dnajc15 ^∗, Mutyh ^∗, Dnajc11 ^∗, Slc25a22 ^∗, Akr7a2 ^∗, Exog ^∗, Abcb10, Cat ^∗, Atp5h, Abce1 ^∗, Fech ^∗, Pisd ^∗, Synj2bp ^∗, Cyb5b ^∗, Mrm1 ^∗, Por ^∗, Trap1 ^∗, Mfn1 ^∗, Slc25a34, Atp5c1 ^∗, Mecr, Prodh, Me3 ^∗, Atp5sl ^∗, Abca9, Samm50 ^∗, Mtx1 ^∗, Hk2 ^∗, Sfxn4, Hk1 ^∗, Letm2 ^∗, Wars2 ^∗, Bcl2l1 ^∗, Mrpl11 ^∗, Ivd ^∗, Slc25a46 ^∗, Etfb ^∗, Pdk2 ^∗, Mobp, Tomm40 ^∗, Atad1 ^∗, Acsm3, Mrpl22 ^∗, Adap2, Hmgcs2 ^∗, Tfrc, Ndufv1 ^∗, Gls ^∗, Bola1 ^∗, Alkbh3 ^∗, Acad11 ^∗, Dap3 ^∗, Comtd1 ^∗
	Mitochondrial outer membrane	11	100	Cyb5r3 ^∗, Mfn1 ^∗, Samm50 ^∗, Mtx1 ^∗, Hk2 ^∗, Hk1 ^∗, Tomm40 ^∗, Bnip3 ^∗, Bcl2l1 ^∗, Cyb5b ^∗, Synj2bp ^∗
	Mitochondrial inner membrane	15	80	Cyb5r3 ^∗, Atp5d ^∗, Uqcrc1 ^∗, Samm50 ^∗, Letm2 ^∗, Cyb5b ^∗, Hmgcs2 ^∗, Slc25a34, Ndufv1 ^∗, Dnajc11 ^∗, Slc25a22 ^∗, Atp5c1 ^∗, Slc25a46 ^∗, Abcb10, Atp5h
	Mitochondrial matrix	12	92	Mrpl11 ^∗, Atp5d ^∗, Acsm3, Pdk2 ^∗, Fech ^∗, Hmgcs2 ^∗, Ivd ^∗, Gls ^∗, Atp5c1 ^∗, Wars2 ^∗, Etfb ^∗, Dap3 ^∗

^∗DEGs that SkQ1 eliminated in OXYS rats. BP: biological process, MF: molecular function, CC: cellular component.