Table 1.

Descriptive Statistics for SNP Weight Sets in ASD TWAS

Study	Tissue	Typea	Individualsb	Featuresc	ASD TWAS Significant
O'Brien (12)	Fetal brain	Gene	67	831	2
O'Brien (12)	Fetal brain	Transcript	67	2865 (2295)	6 (5)
CMC	Dorsolateral prefrontal cortex	Gene	452	5379	1
CMC	Dorsolateral prefrontal cortex	Splicing	452	7735 (3297)	1
NTR	Peripheral blood	Gene	1247	2437	0
YFS	Whole blood	Gene	1264	4657	2
METSIM	Adipose	Gene	563	4637	0
GTEx	Caudate basal ganglia	Gene	100	944	0
GTEx	Cerebellar hemisphere	Gene	89	1512	1
GTEx	Cerebellum	Gene	103	2001	2
GTEx	Cortex	Gene	96	1047	0
GTEx	Frontal cortex BA9	Gene	92	928	1
GTEx	Hippocampus	Gene	81	539	0
GTEx	Hypothalamus	Gene	81	602	2
GTEx	Nucleus accumbens basal ganglia	Gene	93	883	1
GTEx	Putamen basal ganglia	Gene	82	633	0
Total	—	—	—	37,631 (13,243)	19 (14)

Numbers in parentheses for fetal brain transcript level and CMC dorsolateral prefrontal cortex indicate the number of unique genes.

ASD, autism spectrum disorder; BA, Brodmann area; CMC, CommonMind Consortium; GTEx, Genotype-Tissue Expression project; METSIM, Metabolic Syndrome in Men study; NTR, Netherlands Twin Registry; SNP, single nucleotide polymorphism; TWAS, transcriptome-wide association study; YFS, Young Finns Study.

^aType indicates what the features for each dataset represent, i.e., gene-level expression, transcript-level expression, or splicing events.

^bIndividuals in the reference sample used to derive the feature SNP weights.

^cFeatures included in the TWAS for each SNP weight set.