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. 2019 Jul 23;10:616. doi: 10.3389/fgene.2019.00616

Figure 1.

Figure 1

Human genes involved in response to HCMV and related diseases. Summary figure representing the interaction between host genes and HCMV in different phenotypic outcomes based on literature reports as listed and cited in Table 1 . (A) Genes modulating humoral immunity response against HCMV. (B) Innate and adaptive immune response modulating genes unique to and shared between susceptibility to HCMV disease in transplantation, HIV infection, and vertical transmission categories. The grouping of genes among the phenotypic outcomes is deduced based on association results and related literature detailed in Table 1 . “Vertical transmission” category is based on studies of transmission of HMCV from mother to fetus or newborn. “HCMV disease in transplantation” category includes results from solid organ and stem cell transplantation studies. “HCMV disease in HIV infection” category includes results from HIV-infected patients.