Table 2.
Various genetic modifications in the Scnn1b-Tg+ mouse model.
| Genotype | Description | Macrophage infiltration | Neutrophil infiltration | Eosinophil infiltration | Lymphocyte infiltration | Mucous cell metaplasia | Airway mucus obstruction | Distal airspace enlargement | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Tnfα−/−-Scnn1b-Tg+ | Global deletion of Tnfα | No significant difference | No significant difference | No significant difference | No significant difference | No significant difference | No significant difference | No significant difference | (Livraghi et al., [65]) |
| Tnfr1−/−-Scnn1b-Tg+ | Global deletion of Tnfr1 | No significant difference | No significant difference | No significant difference | No significant difference | No significant difference | No significant difference | No significant difference | (Livraghi et al., [65]) |
| Il4rα−/−-Scnn1b-Tg+ | Global deletion of Il4rα | No significant difference | No significant difference | Significantly reduced at PND 10 and 5 weeks of age | No significant difference | Significantly reduced at PND 10 | No significant difference | No significant difference | (Livraghi et al., [65]) |
| Myd88−/−Scnn1b-Tg+ | Global deletion of Myd88 | Significantly higher at PND 10; no significant difference at other observed time-points | Significantly reduced | No significant difference | Lymphoid hyperplasia significantly increased at 8 weeks of age | Significantly reduced at PND 5-7, but not at other time-points | Significantly reduced at PND 5-7, but not at any other observed time-point | Not reported | (Livraghi-Butrico et al., [38]) |
| Ne−/−-Scnn1b-Tg+ | Global deletion of neutrophil elastase | No significant difference | Significantly reduced | No significant difference | No significant difference | Significantly reduced | No significant difference | Significantly reduced | (Gehrig et al., [57]) |
| Il1r−/−-Scnn1b-Tg+ | Global deletion of Il1r | No significant difference | Significantly reduced | No significant difference | No significant difference | Not reported | Significantly reduced | Significantly reduced | (Fritzsching et al., [97]) |
| DTA+-Scnn1b-Tg+ | Partial deficiency of macrophages | No significant difference in total number of macrophage infiltration, significantly reduced in total percentage | Significantly increased | No significant difference | Increased occurrence of lymphoid aggregates in adult mice; significant infiltration in nonemaciated phenotype | Significantly reduced in emaciated phenotype | Significantly reduced in emaciated phenotype | No significant difference | (Saini et al., [51, 53]) |
| Muc5b−/−-Scnn1b-Tg+ | Global deletion of Muc45b | No significant difference | No significant difference | Not reported | Increased lymphoid aggregates, but no significant difference in BALF lymphocytes | Not reported | Significantly reduced | No significant difference | (Livraghi-Butrico et al., [108]) |
| Muc5ac−/−-Scnn1b-Tg+ | Global deletion of Muc5ac | No significant difference | No significant difference | Not reported | No significant difference in incidence of lymphoid aggregates | Not reported | Significantly reduced | Not reported | (Livraghi-Butrico et al., [108]) |
| Spdef−/−-Scnn1b-Tg+ | Global deletion of Spdef | No significant difference | Significantly increased in neonates | No significant difference | No significant difference | Not reported | No significant difference | Not reported | (Chen et al., [109]) |