Table 5.
Clinical characteristics of participants with T1D in different genotypes of SNPs in the NLRP1 gene.
| Characteristics | SNP | |||||||
|---|---|---|---|---|---|---|---|---|
| rs11651270 | rs2670660 | |||||||
| CC | CT | TT | p value | GG | GA | AA | p value | |
| Sample size | 23 | 145 | 342 | — | 14 | 123 | 373 | — |
| Sex (men/women) | 12/11 | 80/65 | 183/159 | 0.931 | 8/6 | 70/53 | 197/176 | 0.710 |
| Age of onset (years) | 29 (13-37) | 23 (14-33) | 17 (10-32) | 0.001∗ | 27 (15-35) | 21 (13-35) | 18 (10-32) | 0.057 |
| T1D duration (months) | 4.00 (0.23-24.00) | 3.00 (0.33-18.00) | 5.00 (0.56-24.00) | 0.590 | 0.59 (0.12-6.00) | 5.00 (0.47-36.00) | 5.00 (0.50-16.00) | 0.068 |
| BMI (kg/m2) | 19.63 (17.94-21.23) | 18.80 (16.80-20.80) | 18.51 (16.30-20.70) | 0.155 | 19.50 (18.52-20.59) | 18.91 (16.80-21.08) | 18.60 (16.39-20.67) | 0.187 |
| FCP (pmol/L) | 93.64 (4.55-169.75) | 79.63 (21.18-190.98) | 74.00 (16.10-156.07) | 0.602 | 148.60 (53.99-213.88) | 79.00 (18.89-164.80) | 73.54 (15.92-158.87) | 0.184 |
| PCP (pmol/L) | 169.83 (15.52-259.69) | 152.81 (47.80-318.66) | 135.00 (34.90-263.40) | 0.402 | 220.88 (138.68-369.63) | 161.30 (40.83-284.34) | 133.85 (35.94-261.85) | 0.129 |
| HbA1c (%) | 10.10 (8.65-14.00) | 9.75 (7.73-12.48) | 10.10 (7.70-12.80) | 0.611 | 12.50 (9.23-14.35) | 9.70 (7.70-12.50) | 10.10 (7.70-12.80) | 0.153 |
| GADA positive% | 91.30% | 90.34% | 87.39% | 0.587 | 92.86% | 86.18% | 88.98% | 0.611 |
| IA-2A positive% | 52.38% | 42.42% | 48.41% | 0.449 | 38.46% | 45.05% | 47.81% | 0.726 |
| ZnT8A positive% | 45.00% | 25.62% | 32.12% | 0.162 | 35.71% | 25.25% | 32.46% | 0.372 |
| GADA titer (U/mL) | 448.33 (248.47-850.88) | 328.43 (91.06-788.30) | 288.81 (78.79-755.57) | 0.289 | 756.39 (271.01-929.77) | 266.86 (78.81-728.13) | 313.80 (82.87-765.60) | 0.127 |
| IA-2A titer (U/mL) | 361.12 (62.69-790.02) | 190.66 (45.07-659.52) | 186.51 (52.12-663.96) | 0.618 | 62.69 (28.90-575.57) | 113.51 (41.42-575.28) | 231.99 (59.24-695.60) | 0.143 |
SNP: single-nucleotide polymorphisms; BMI: body mass index; FCP: fasting C-peptide; PCP: 2 h postprandial C-peptide; HbA1c: glycated hemoglobin; GADA: glutamic acid decarboxylase antibody; IA-2A: protein tyrosine phosphatase antibody; ZnT8A: zinc transporter 8 antibody.