Fig. 1.

Unsupervised multivariate analysis of the global metabolic changes in the cerebral cortices of mice. Partial least squares projection to latent structures discriminant analysis (PLS-DA) score plots of the first two principal components (PC1 and PC2) showing the effect of infection on the metabolic profile of cerebral cortices at 7, 14 and 21 days post-infection (dpi). Distinct metabolic differences were observed between infected and control mouse groups particularly at 14 and 21 dpi. POS and NEG indicate positive ion mode and negative ion mode, respectively