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. 2019 Jul 30;17:62. doi: 10.1186/s12915-019-0679-8

Fig. 3.

Fig. 3

Process of identifying TFs regulating phenotypic variation. A hypergeometric test is used to test the overlap between a TF’s “binding change SNPs,” based on presence within ChIP peaks from ENCODE and high Delta-MOP score, and “phenotype-associated SNPs,” i.e., eQTLs of genes whose expression correlates with phenotype, located within cis-regulatory regions of the gene identified by Hi-C data. A TF is considered significant to the phenotype if the FDR q value is below 0.05