Table 2.
The prevalence and change of genotype in ESBL-producing E. coli isolated from hospitalised horses in two different cohorts from the same equine hospital sampled 10 years apart
| Genotype (322) | 2008 cohort (n = 135) | Prevalence (95% CI) | 2017 cohort (n = 187) | Prevalence (95% CI) | Change (%) | P -value |
|---|---|---|---|---|---|---|
| blaSHV (105) | 86 | 63.7 (55.3–71.3) | 19 | 10.2 (6.6–15.3) | −53.5 | < 0.001 |
| blaTEM (183) | 116 | 85.9 (79.1–90.8) | 67 | 35.8 (29.3–42.9) | −50.1 | < 0.001 |
| blaCTX-M (253) | 76 | 56.3 (47.9–64.4) | 177 | 94.6 (90.4–97.1) | + 37.8 | < 0.001 |
| blaCTX-M Gr1 (193) | 17 | 12.6 (8.0–19.2) | 176 | 94.1 (89.8–96.7) | + 81.5 | < 0.001 |
| CTX-M-1 (86) | 17 | 100 (81.6–100) | 69 | 39.2 (32.3–46.6) | −60.8 | < 0.001 † |
| CTX-M-15 (107) | 0 | 0 (0–18.4) | 107 | 60.8 (53.4–67.7) | + 60.8 | |
| blaCTX-M Gr2 (10) | 9 | 6.7 (3.6–12.2) | 1 | 0.5 (0–3.0) | −6.1 | 0.002 † |
| blaCTX-M Gr9 (50) | 50 | 37.0 (29.4–45.4) | 0 | 0.0 (0.0–2.0) | −37.0 | < 0.001 † |
| qnr A (27) | 2 | 1.5 (0.4–5.2) | 25 | 13.4 (9.2–19.0) | + 11.9 | < 0.001 † |
| qnr B (48) | 30 | 22.2 (16.0–30.0) | 18 | 9.6 (6.2–14.7) | −12.6 | 0.003 |
| qnr S (19) | 9 | 6.7 (3.6–12.2) | 10 | 5.4 (2.9–9.6) | − 1.3 | 0.8 |
P-value provided for Chi-squared test apart from where † indicates use of Fisher’s Exact Test