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. Author manuscript; available in PMC: 2019 Jul 30.
Published in final edited form as: Structure. 2018 Nov 21;27(1):196–206.e6. doi: 10.1016/j.str.2018.10.007

Figure 2. Neutralization, B cell ontogeny, and paratope characteristics for 20 classes of broadly neutralizing antibodies.

Figure 2.

(A) The broadest neutralizing antibody from each class was chosen as representative. (B) Neutralization properties. Bar graphs show breadth and potency of each representative antibody on the 208-isolate panel, with dotted line showing averages. (C) Features of B cell ontogeny. CDR H3 lengths are defined based on Kabat nomenclature. @ indicates that antibody b12 is derived from a phage library. (D) Paratope properties. “*” indicate structures determined in deglycosylated gp120-core context; “&” indicates structures determined in partially glycosylated gp120-core context; “#” indicates structures determined with V1/V2 scaffold. Structures denoted with “*”, “&”, or “#” were included in calculations of the category averages for protruding loop numbers, but not for paratope surface area. P-values were determined using two-tailed Mann-Whitney test. See also Figure S1, Table S2 and Datasets S2–S4.