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. Author manuscript; available in PMC: 2019 Jul 30.
Published in final edited form as: Structure. 2018 Nov 21;27(1):196–206.e6. doi: 10.1016/j.str.2018.10.007

Figure 5. Factors affecting re-elicitation.

Figure 5.

(A) Categories, classes, and representative structures. (B) Recombination properties. Bar graphs show average VH gene frequency and paratope properties of D gene, N addition and CDR H3 for each representative antibody. Average VH gene frequencies report from healthy donors in PRJNA304166. D gene and N additions occurring at the junctions are from IMGT V-quest (http://www.imgt.org/IMGT_vquest/vquest). # indicates that antibody missing nucleotide sequences at junction. (C) SHM likelihood. Bar graphs show the paratope contributed from SHM (1st amino acid to the 2nd conserved Cys) and rare SHM. @ indicates that antibody missing nucleotide sequence. See also Table S2.