Table 1.

SGLT1/2‐IC₅₀‐values of the most active SGLT1 inhibitor per chemical cluster

Compound	Cluster	Type	SGLT1‐IC50 (μmol/L)			SGLT2‐IC50 (μmol/L)
			n	Mean	SD	n	Mean	SD
Phloridzin	Glycosides	Natural	25+	0.34	0.14	29+	0.16	0.1
(+)‐pteryxin	APC	Natural	5	12	2	4	9	4
(+)‐ε‐viniferin	Viniferin‐like	Natural	4	58	18	2	110, 110	n.a.
Quinidine	Quinidine‐like	Natural	2	51, 74	n.a.	2	72, 40	n.a.
Cloperastine	Diphenhydramine‐like	Synthetic	4	9	3	6	9	7
Bepridil	Trimipramine‐like	Synthetic	4	10	5	8	14	12
Trihexyphenidyl	Trihexyphenidyl‐like	Synthetic	3	12	1	7	20	13
Bupivacaine	Bupivacaine‐like	Synthetic	4	23	14	5	43	29

IC₅₀‐values of the most active novel inhibitors from chemical clusters presented in Figure 2. Results are means with SD from biological replicates, or individual measurements. n.a. = not applicable. + = original dataset contained a statistical outlier that was excluded from calculation of the mean and SD.