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. 2019 Jul 23;9:628. doi: 10.3389/fonc.2019.00628

Figure 1.

Figure 1

Chest CT and cranial MRI. (Left) Chest CT performed on the day of admission (day 1) and after treatment with afatinib for 71 days (day 98) and 190 days (day 217). The lung lesions (blue arrows) were reduced in size after treatment with afatinib for 71 days (day 98), and the effect was maintained after a further 119 days of treatment (day 217). (Right) Enhanced cranial MRI T2 FLAIR scans performed on day 21 and after treatment with afatinib for 77 days (day 104) and 194 days (day 221). The cranial MRI scan on day 21 showed high-intensity linear shadows in the medulla oblongata, pons, and ventral and dorsal midbrain, which were considered to be leptomeningeal metastases. The cranial scan on day 104 revealed similar abnormalities to those detected on day 21. However, the abnormal signals in the medulla oblongata, pons, and ventral and dorsal midbrain on day 221 were decreased in comparison to those on days 21 and 104.