Figure 2.

The gcm mutation positively correlates with the epileptic phenotype in double-crossed (F2) GAERS versus NEC rats. a, Percentage of recording time spent in seizure activity. Animals homozygous for the mutation spend more time in seizure activity than animals null for the gcm (p < 0.05, Mann–Whitney one-tailed test). b, Number of seizures. Animals homozygous for the gcm experience more seizures than animals null for the mutation (p < 0.05, Mann–Whitney one-tailed test). c, The interval between the seizures was significantly shorter for animals homozygous for the mutation compared with animals null for the mutation (p < 0.05, Mann–Whitney one-tailed test). d, The length of individual seizures did not significantly differ between the genotypes (p > 0.05, Mann–Whitney one-tailed test). e, The cycle frequency of the spike-and-wave discharges (hertz) did not significantly differ between the genotypes (p > 0.05, Mann–Whitney one-tailed test). +/+ animals are null for the gcm, +/m animals have one copy of the gcm, and m/m animals are homozygous for the gcm. Data are expressed as mean ± SEM. *p < 0.05.