. 2009 Nov 11;29(45):14108–14119. doi: 10.1523/JNEUROSCI.2055-09.2009

Table 1.

Morphological phenotypes of Iba1 plus microglia and area fraction for CD11b plus activated microglia in APP/PS1 doubly transgenic mice subjected to Aβ immunotherapy

Region	Microglia type/Area fraction	Control antibody	Aβ Immunotherapy
SGZ/GCL	% ramified Iba1⁺	36.4 ± 22.5	24.4 ± 4.9
	% intermediate Iba1⁺	49.3 ± 3.3	57 ± 4.8
	% amoeboid Iba1⁺	13 ± 2.9	15.5 ± 2.7
	% round Iba1⁺	1.3 ± 0.5	3.2 ± 1.4
Hilus	% ramified Iba1⁺	20.5 ± 2.9	12.4 ± 3.0
	% intermediate Iba1⁺	57.7 ± 7.2	59.8 ± 3.4
	% amoeboid Iba1⁺	13.7 ± 4.2	21.5 ± 4.7
	% round Iba1⁺	3.3 ± 1.1	6.3 ± 1.1
Septum	% ramified Iba1⁺	18.3 ± 3.3	17.7 ± 3.4
	% intermediate Iba1⁺	57.7 ± 7.2	49.8 ± 3.7
	% amoeboid Iba1⁺	15.4 ± 5.3	21.4 ± 2.9
	% round Iba1⁺	8.6 ± 3.2	11.1 ± 2.7
Hippocampus	% area CD11b⁺	0.50 ± 0.10	0.65 ± 0.11
Septum	% area CD11b⁺	0.84 ± 0.20	0.98 ± 0.31

Morphological subtypes of Iba1 plus microglia: ramified and intermediate represent quiescent and amoeboid and round represent activated microglia. No significant differences were observed between groups. Values are means ± SEM; n = 5 (control antibody) and n = 7 (Aβ immunotherapy).