Figure 6.

Sustained activation of the OFC predicts the inhibition of shock-evoked activity in the amygdala. Counterirritation produced a robust and sustained activation of lateral OFC ipsilateral to the foot immersion that was strongly correlated to analgesia (top brain slice). Counterirritation also produced a robust inhibition of shock-evoked activity in the left amygdala, contralateral to the shock (bottom brain slice). The activity of these two structures was strongly associated, as illustrated by the scatter plot on the right.