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. 2009 Jan 21;29(3):669–677. doi: 10.1523/JNEUROSCI.3921-08.2009

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Copyright © 2009 Society for Neuroscience 0270-6474/09/290669-09$15.00/0

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Figure 1. — CaMKII inhibition with Ant-AIP-2 modulates NR2B localization in the postsynaptic fraction in cultured neurons. Western blot analysis of the homogenate (Homo) and postsynaptic TIF obtained from control and Ant-AIP-2 (10 μm, 2 h)-treated DIV14 primary hippocampal cultures. The same amount of proteins were loaded in each lane. Ant-AIP-2 treatment leads to a decreased NR2B localization in the TIF leaving the total amount of NR2B unaltered. NR2A and PSD-95 immunostaining in the TIF were not affected. Notably, αCaMKII levels in the TIF were also decreased (NR2B TIF, p < 0.001, Ant-AIP-2 vs Control; αCaMKII TIF, p < 0.05, Ant-AIP-2 vs Control).