Figure 2.

Prevalence and characteristics of seizures in APdE9 mice. A, The cumulative proportion (percentage) of APdE9 mice (n = 20) remaining seizure free during the video-EEG monitoring as a function of their true biological age. The gap between 15 and 18 weeks of age indicates the interval between the first (2 weeks) and the second (1 week) recording periods. WT, Wild type. B, Prevalence and characteristics of seizures in APdE9 mice (n = 20). In this table, the video-EEG recording has been divided into three periods (Per) of 1 week each. Mean dur., Mean seizure duration; Mean beh. score, mean behavioral score in Racine's scale; Gen. sz. (%), percentage of generalized seizures of all seizures. The two rightmost columns represent alterations in hippocampal calbindin (CB) and NPY staining. For CB staining, + means presence of normal immunoreactivity; for NPY staining, + means presence of ectopic immunoreactivity in mossy fibers. N/A, Data not available [we chose 7 APdE9 mice with at least one unprovoked seizure and 7 APdE9 mice with no detectable seizures for immunostaining together with 7 wild-type mice (not included in the table)].