Table 3.
The EC50 values for all the splicing and editing combinations performed in the present study
| ac |
bd |
|||||
|---|---|---|---|---|---|---|
| EC50, μm | SEM | n | EC50, μm | SEM | n | |
| R122G plus I283V plus N294D | 4.2 | 1 | 4 | 192.9 | 57.3 | 4 |
| R122G plus N294D plus M360V | 8.5 | 0.8 | 4 | 182.8 | 19.2 | 4 |
| R122G plus I283V plus M360V | 24.9 | 12.3 | 5 | 143.5 | 13.4 | 4 |
| Fully edited | 15.4 | 3.3 | 5 | 118.6 | 32.2 | 7 |
| M360V | 20.6 | 4.2 | 5 | 95 | 36.1 | 3 |
| N294D plus M360V | 4.5 | 0.6 | 5 | 83.6 | 19.4 | 4 |
| R122G plus M360V | 11.3 | 2.5 | 5 | 81.8 | 8.4 | 5 |
| I283V | 4.7 | 1.9 | 5 | 72.6 | 36.5 | 4 |
| N294D | 11.1 | 4.3 | 5 | 66.9 | 14.7 | 4 |
| R122G | 18.5 | 4.5 | 3 | 65.6 | 7.4 | 4 |
| Unedited | 2.7 | 0.5 | 5 | 54 | 16.6 | 4 |
| R122G plus I283V | 5.3 | 1.6 | 5 | 53.2 | 13.8 | 5 |
| R122G plus N294D | 6.4 | 1.2 | 4 | 52.6 | 8.2 | 6 |
| I283V plus M360V | 4.9 | 1.7 | 4 | 52.3 | 12.2 | 3 |
| I283V plus N294D plus M360V | 3.7 | 0.4 | 5 | 42.3 | 14.4 | 5 |
| I283V plus N294D | 3.2 | 0.2 | 5 | 27.4 | 3.9 | 6 |
The SEM and number of experiments from different batches of oocytes are also given. The EC50 values are arranged in descending order for the bd splice variant.