Figure 2.

A 10 min period of 8 Hz rhythmic whisker stimulation induces a long-lasting and input-specific potentiation of whisker-evoked brain responses under isoflurane anesthesia. A, Examples of SEP waveforms (n = 8) recorded under isoflurane anesthesia over the left and right barrel cortices in responses to respective contralateral deflections 20 min before (baseline) and 60 min after (post-stim) 8 Hz (right) whisker stimulation. B, Pooled averages of the SEP amplitudes from the three baseline and 30, 60, and 90 min after 8 Hz whisker stimulation, normalized against the baseline. Asterisks indicate significant differences with baseline at p < 0.05. Potentiated responses are limited to the left barrel cortex, contralateral to the 8 Hz whisker stimulation.