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. 2009 May 13;29(19):6276–6284. doi: 10.1523/JNEUROSCI.4304-08.2009

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Copyright © 2009 Society for Neuroscience 0270-6474/09/296276-09$15.00/0

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Figure 3. — Wallerian degeneration occurs normally in NMNAT1-Tg or Wld^s(W258A)-Tg. Axonal degeneration was examined in a sciatic nerve injury model. Neurofilament immunoreactivity in the distal segment of the transected sciatic nerve was examined in NMNAT1-Tg (lines 744 and 748), wld^s mice, Wld^s(W258A)-Tg (lines 1032 and 1037), as well as in wild-type control, at 3 and 4 d after nerve lesion and compared with uninjured control by immunoblot analysis (A), and on longitudinal sections by immunohistochemistry (B). α-Tubulin served as a loading control in A. Scale bar, 50 μm. Note that even subtle protection of axons was not observed in NMNAT1-Tg or Wld^s(W258A)-Tg.