Table 1.
Clinical characteristics (experiments 1 and 2)
| Patient | Experiment | Gender | Age | UPDRS part III (motor section) |
H & Y | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Right hand | Left hand | Right foot | Left foot | Other | Total | |||||
| 1 | 2 | 2 | 55 | 11 | 7 | 5 | 3 | 6 | 32 | 2 |
| 2 | 1 | 1 | 39 | 13 | 3 | 4 | 0 | 6 | 26 | 2 |
| 3 | 1 | 1 | 48 | 15 | 3 | 3 | 1 | 16 | 38 | 2.5 |
| 4 | 1 | 2 | 51 | 8 | 5 | 4 | 2 | 8 | 27 | 2 |
| 5 | 1 | 1 | 48 | 10 | 3 | 5 | 0 | 14 | 32 | 3 |
| 6 | 1 | 1 | 53 | 8 | 1 | 2 | 1 | 7 | 19 | 2 |
| 7 | 1 | 1 | 50 | 8 | 1 | 3 | 1 | 7 | 20 | 1.5 |
| 8 | 1–3 | 2 | 59 | 11 | 5 | 4 | 1 | 7 | 28 | 2 |
| 9 | 1–3 | 1 | 68 | 12 | 5 | 3 | 3 | 7 | 30 | 2 |
| 10 | 1–3 | 1 | 65 | 5 | 2 | 3 | 1 | 3 | 14 | 2 |
| 11 | 1–3 | 1 | 56 | 10 | 5 | 4 | 2 | 2 | 23 | 2 |
| 12 | 1–3 | 1 | 34 | 10 | 0 | 4 | 0 | 8 | 22 | 1.5 |
| 13 | 1–3 | 1 | 50 | 10 | 5 | 4 | 2 | 13 | 34 | 3 |
| 14 | 1–3 | 1 | 53 | 11 | 3 | 4 | 2 | 7 | 27 | 2 |
| 15 | 1–3 | 2 | 67 | 8 | 2 | 6 | 4 | 5 | 25 | 2 |
| 16 | 1–3 | 1 | 65 | 4 | 0 | 2 | 0 | 6 | 12 | 1.5 |
| 17 | 1, 3 | 2 | 43 | 13 | 8 | 3 | 1 | 6 | 31 | 2 |
| 18 | 1, 3 | 2 | 56 | 10 | 3 | 1 | 1 | 4 | 19 | 2 |
| Mean | 12 men | 53.3 | 9.8 | 3.4 | 3.6 | 1.4 | 7.3 | 25.5 | 2.1 | |
| SD | 9.4 | 2.7 | 2.3 | 1.2 | 1.1 | 3.6 | 7.0 | 0.4 | ||
Eighteen patients with idiopathic Parkinson's disease were tested in a practically-defined off-state [more than 12 h after having taken their last medication (Langston et al., 1992)]. All patients were consistent right-handers. Patients had markedly asymmetric symptoms lateralized to the right side of their body, and more symptoms in their hands than in their feet. Different patients participated in different experiments (see second column). Patients 8–18 were retested approximately 1 year later when participating in experiment 3 (for clinical scores, see supplemental Table 1, available at www.jneurosci.org as supplemental material). Highest possible UPDRS-III score is 108 points. The highest possible UPDRS score for each side is 36 points: 24 points for the hand and 12 points for the foot. H & Y, Hoehn and Yahr rating scale (highest stage is 5). Gender: 1, man; 2, woman.