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NMDAR-mediated currents evoked by glutamate application in CA3-GluN2B-KO mice. A, Currents were evoked by iontophoretic glutamate (Glu) application to the soma or dendrites of CA3 pyramidal cells. The downward and upward traces show non-NMDAR-mediated EPSCs at −80 mV (a) and NMDAR- and/or non-NMDAR-mediated EPSCs at +50 mV (b–d), respectively. B, AMPAR-mediated (b − c) and NMDAR-mediated (c − d) responses.
