Figure 5.

IGF-1 increases the number of amacrine dopaminergic cells. The number of TH-positive amacrine cells is significantly higher in P10 IGF-1-treated non-EE rats than in non-EE untreated animals (67 ± 5 vs 46 ± 3 cells/mm²). The effect of IGF-1 administration is comparable with that induced by EE: the number of TH-positive amacrine cells of P10 IGF-1-treated non-EE rats did not differ from that of P10 EE rats (66 ± 3 cells/mm²) (one-way ANOVA, p = 0.005, post hoc Tukey's test; non-EE untreated eyes vs IGF-1-treated eyes, p = 0.008 (asterisk); non-EE untreated eyes vs EE untreated eyes, p = 0.015 (asterisk); EE untreated eyes vs IGF-1-treated eyes, p = 0.998). Error bars represent SEM.