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. 2009 Jul 22;29(29):9244–9254. doi: 10.1523/JNEUROSCI.1532-09.2009

Figure 2.

Figure 2.

Cerebella from Afg3l2+/Emv66 mice show alteration of the PC dendritic tree and reduced thickness of the ML. Calbindin immunohistochemistry on cryostat sections of the midsagittal portion of the cerebellum of Afg3l2+/Emv66 and control mice at 6 months (top) and 12 months (bottom) is shown. In the mutant, several PCs disappear, leaving empty spaces in the PC monolayer (arrowheads). PC dendrites appear hypertrophic and less arborized (arrows), which leads to the ML's reduced thickness compared with controls in Afg3l2+/Emv66. Scale bar, 50 μm.