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. 2009 Jul 22;29(29):9244–9254. doi: 10.1523/JNEUROSCI.1532-09.2009

Figure 5.

Figure 5.

Apoptotic cell death of cerebellar GCs and massive gliosis in the granule layer in Afg3l2+/Emv66 mice. a, b, e, f, TUNEL-labeled cells (red) in cerebellar sections of Afg3l2+/Emv66 mice and syngenic controls at 6 and 12 months. At both ages, TUNEL-positive cells appear located in the GC layer (b, f). No TUNEL-positive staining was detected in PCs. c, d, g, h, Immunofluorescence on cerebellar sections of Afg3l2+/Emv66 mice and syngenic controls at 6 and 12 months showed a strong GFAP immunoreactivity in the granule layer. Scale bar, 100 μm.