Table 1.
SHIRPA primary tests; SHIRPA primary screening is used to assess sensory–motor function of Afg3l2+/Emv66 and syngenic wild-type mice (n = 10) at 4, 6, and 12 months
| Behaviors | 4 months |
6 months |
12 months |
|||
|---|---|---|---|---|---|---|
| +/+ | +/Emv66 | +/+ | +/Emv66 | +/+ | +/Emv66 | |
| Negative geotaxis | 0.0 ± 0.0 | 0.9 ± 1.0** | 0.0 ± 0.0 | 1.1 ± 0.67** | 0.0 ± 0.0 | 1.67 ± 1.03* |
| Gait | 0.0 ± 0.0 | 0.4 + 0.5 | 0.0 ± 0.0 | 0.3 ± 0.5* | 0.0 ± 0.0 | 2 ± 0* |
| Transfer arousal | 5 ± 0.0 | 5 ± 0.0 | 5 ± 0.0 | 5 ± 0.0 | 5 ± 0.0 | 3.67 ± 1.03* |
| Pelvic elevation | 2 ± 0.0 | 2 ± 0.0 | 2 ± 0.0 | 2 ± 0.0 | 2 ± 0.0 | 1 ± 0.0* |
Data are expressed as mean ± SD (Mann–Whitney nonparametric test; *p < 0.05; **p < 0.001).