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. 2009 May 27;29(21):6982–6988. doi: 10.1523/JNEUROSCI.0443-09.2009

Figure 4.

Figure 4.

Enhanced AMPA receptor-mediated network events and intrinsic firing in neonatal NKCC1−/− CA3 pyramidal neurons in the absence of GABAA signaling. A, Top traces, The effect of the AMPA/kainate antagonist NBQX (50 μm) on fGDPs in a WT slice. Bottom traces, Simultaneous fp and voltage-clamp (Vh of −60 mV; [Cl−]p = 49 mm) recordings from an NKCC1−/− slice showing the effect of 50 μm NBQX. B, The effect of 100 μm picrotoxin on fGDPs in a WT and an NKCC1−/− slice and a further addition of 20 μm GYKI53655. C, Left, mEPSCs recorded in WT and NKCC1−/− CA3 pyramidal neurons. Right, Normalized cumulative peak mEPSC amplitude histograms obtained from 25 WT and 20 NKCC1−/− CA3 pyramidal neurons. D, Cell-attached recordings from WT and NKCC1−/− CA3 pyramidal neurons in the presence of NBQX, AP-5, and picrotoxin.